Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7.1
USERS' SCORE
Good
Based on 8 Reviews
8
Supplement Facts
Serving Size: 3 Capsules
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine hydrochloride)
10 mg
588%
Magnesium (as magnesium aspartate, magnesium oxide)
435 mg
104%
Zinc (as zinc aspartate, zinc monomethionine, zinc oxide)
28 mg
255%
Top Medical Research Studies
7
We explored the relationship between serum zinc levels and chronic fatigue syndrome (CFS) in a study that compared patients with CFS to normal volunteers. By using an atomic absorption method, we measured serum zinc concentrations and found that those suffering from CFS had significantly lower levels of zinc compared to healthy individuals.
Interestingly, we observed a trend indicating that lower zinc levels correlated with greater CFS severity. Patients also reported a negative correlation between their zinc levels and their subjective experiences of infection. This suggests that zinc plays a role in the immune dysfunction commonly seen in CFS.
Furthermore, we noted that lower serum zinc was associated with higher levels of inflammatory markers and certain defects in the early activation of T cells. Since zinc acts as a potent antioxidant, our findings indicate that CFS is linked to increased oxidative stress in these patients. Given this, it may be beneficial for some CFS patients to consider zinc supplements as part of their treatment approach.
Interestingly, we observed a trend indicating that lower zinc levels correlated with greater CFS severity. Patients also reported a negative correlation between their zinc levels and their subjective experiences of infection. This suggests that zinc plays a role in the immune dysfunction commonly seen in CFS.
Furthermore, we noted that lower serum zinc was associated with higher levels of inflammatory markers and certain defects in the early activation of T cells. Since zinc acts as a potent antioxidant, our findings indicate that CFS is linked to increased oxidative stress in these patients. Given this, it may be beneficial for some CFS patients to consider zinc supplements as part of their treatment approach.
Read More
8
Magnesium potentially benefits CFS patients
We investigated the relationship between magnesium levels in red blood cells and chronic fatigue syndrome (CFS). A case-control study revealed that CFS patients had lower magnesium levels than healthy individuals.
In a randomized, double-blind trial, 32 CFS patients received either magnesium sulphate or a placebo for six weeks. Those treated with magnesium reported significant improvements in energy, emotional wellbeing, and pain relief, with twelve out of fifteen feeling better.
In contrast, only three out of seventeen patients on placebo reported any improvement. Overall, these findings suggest that magnesium treatment may positively impact the wellbeing of those suffering from CFS.
In a randomized, double-blind trial, 32 CFS patients received either magnesium sulphate or a placebo for six weeks. Those treated with magnesium reported significant improvements in energy, emotional wellbeing, and pain relief, with twelve out of fifteen feeling better.
In contrast, only three out of seventeen patients on placebo reported any improvement. Overall, these findings suggest that magnesium treatment may positively impact the wellbeing of those suffering from CFS.
Read More
7
We aimed to understand the effects of magnesium sulfate treatment on a patient with chronic fatigue syndrome. The case involved a 29-year-old woman experiencing severe fatigue alongside various symptoms, including swelling lymph nodes and muscle pain.
After other treatments failed to provide relief, we administered magnesium sulfate intravenously once a week. Remarkably, after six weeks, the patient reported a significant reduction in fatigue and improved daily functioning, eventually leading to her discharge from the hospital.
After other treatments failed to provide relief, we administered magnesium sulfate intravenously once a week. Remarkably, after six weeks, the patient reported a significant reduction in fatigue and improved daily functioning, eventually leading to her discharge from the hospital.
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Most Useful Reviews
9
Relieves fatigue effectively
This product effectively alleviates fatigue. I consume it when I exercise rigorously, and I notice I feel less exhausted the next day. Additionally, it provides excellent sleep quality, making it a good choice for a restorative night's rest.
Read More
7.5
Boosted energy
3 people found this helpful
Working formula. Strength training often happens late in the evening, leaving little time for recovery, resulting in fatigue in the morning. However, thanks to this ZMA formula from Utrezky, I feel invigorated, full of strength and energy. The value for money is impeccable.
Read More
7.5
Better sleep quality
Before going to bed, I recommend drinking it as it improves sleep quality and alleviates fatigue.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7.1
- All Researches
9
We evaluated the effects of zinc treatment on individuals with long COVID, focusing on how it relates to chronic fatigue syndrome. Our study involved 58 patients who underwent a unique therapy called Epipharyngeal Abrasive Therapy (EAT), which utilized zinc chloride as an anti-inflammatory agent for the epipharynx.
Participants were treated once a week for a month, and we measured the intensity of their symptoms, specifically fatigue, headaches, and attention disorders, using a visual analog scale (VAS). Remarkably, we found that EAT reduced inflammation in the epipharynx and resulted in significant improvements in the reported intensity of these symptoms.
We believe these findings highlight the potential role of zinc in managing symptoms associated with long COVID and possibly chronic fatigue syndrome. While the evidence is encouraging, it remains essential to conduct more in-depth research to truly understand the specific effects of zinc and ensure these benefits are consistently reproducible.
Participants were treated once a week for a month, and we measured the intensity of their symptoms, specifically fatigue, headaches, and attention disorders, using a visual analog scale (VAS). Remarkably, we found that EAT reduced inflammation in the epipharynx and resulted in significant improvements in the reported intensity of these symptoms.
We believe these findings highlight the potential role of zinc in managing symptoms associated with long COVID and possibly chronic fatigue syndrome. While the evidence is encouraging, it remains essential to conduct more in-depth research to truly understand the specific effects of zinc and ensure these benefits are consistently reproducible.
Read More
8
Beta-glucan shows cognitive benefits
We conducted a study exploring the effects of beta-glucan combined with vitamins, including vitamin B6, on individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). This research involved a 36-week trial where 65 participants were split into two groups: one received a daily supplement containing beta-glucan and vitamins, while the other received a placebo.
While the beta-glucan supplementation showed promising results in reducing cognitive fatigue, the specific impact of vitamin B6 on chronic fatigue syndrome was not clearly determined. This is because vitamin B6 was part of a combination treatment, making it difficult to assess its isolated benefits.
Ultimately, we observed that yeast-derived beta-glucan might hold potential in alleviating cognitive challenges associated with ME/CFS, which opens up avenues for further research. However, it’s important to remember that additional studies are needed to fully understand how vitamin B6 and other components contribute to this condition.
While the beta-glucan supplementation showed promising results in reducing cognitive fatigue, the specific impact of vitamin B6 on chronic fatigue syndrome was not clearly determined. This is because vitamin B6 was part of a combination treatment, making it difficult to assess its isolated benefits.
Ultimately, we observed that yeast-derived beta-glucan might hold potential in alleviating cognitive challenges associated with ME/CFS, which opens up avenues for further research. However, it’s important to remember that additional studies are needed to fully understand how vitamin B6 and other components contribute to this condition.
Read More
8
Magnesium potentially benefits CFS patients
We investigated the relationship between magnesium levels in red blood cells and chronic fatigue syndrome (CFS). A case-control study revealed that CFS patients had lower magnesium levels than healthy individuals.
In a randomized, double-blind trial, 32 CFS patients received either magnesium sulphate or a placebo for six weeks. Those treated with magnesium reported significant improvements in energy, emotional wellbeing, and pain relief, with twelve out of fifteen feeling better.
In contrast, only three out of seventeen patients on placebo reported any improvement. Overall, these findings suggest that magnesium treatment may positively impact the wellbeing of those suffering from CFS.
In a randomized, double-blind trial, 32 CFS patients received either magnesium sulphate or a placebo for six weeks. Those treated with magnesium reported significant improvements in energy, emotional wellbeing, and pain relief, with twelve out of fifteen feeling better.
In contrast, only three out of seventeen patients on placebo reported any improvement. Overall, these findings suggest that magnesium treatment may positively impact the wellbeing of those suffering from CFS.
Read More
We investigated the impact of a 3-month supplementation with a special synbiotic mixture on adults suffering from post-COVID-19 chronic fatigue syndrome (ME/CFS). This study was thoughtfully designed as a placebo-controlled, double-blind trial involving 26 participants. The intention was to see how this synbiotic, which notably contains zinc among other components, would influence patients' overall experiences, exercise tolerance, and metabolism in tissues affected by fatigue.
The promising findings indicated that taking the synbiotic mixture for three months improved metabolism and helped alleviate some clinical features associated with post-COVID fatigue syndrome. However, it's important to note that because zinc was part of this mixture, the study does not allow us to draw clear conclusions about zinc alone and its effects on chronic fatigue syndrome.
While our research shows that synbiotics may offer a safe and beneficial approach to managing symptoms of ME/CFS following COVID-19, further investigations are needed to fully understand the role of each component, including zinc, before making any strong recommendations for its use in this context.
The promising findings indicated that taking the synbiotic mixture for three months improved metabolism and helped alleviate some clinical features associated with post-COVID fatigue syndrome. However, it's important to note that because zinc was part of this mixture, the study does not allow us to draw clear conclusions about zinc alone and its effects on chronic fatigue syndrome.
While our research shows that synbiotics may offer a safe and beneficial approach to managing symptoms of ME/CFS following COVID-19, further investigations are needed to fully understand the role of each component, including zinc, before making any strong recommendations for its use in this context.
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8
We conducted a clinical trial to examine how an oral food supplement (OFS) could impact patients suffering from long COVID, particularly focusing on inflammation and fatigue. This was a robust study design, featuring a double-blind, placebo-controlled setup that included 2 capsules of the supplement daily over two months.
The supplement contained a mix of ingredients like rosehip, propolis, royal jelly, zinc, and vitamin C. While zinc was part of the mix, we observed significant results in inflammation reduction through various parameters, such as a decrease in the neutrophil-to-lymphocyte ratio and C-reactive protein levels. However, we couldn’t isolate zinc's effects individually, as it was evaluated alongside other components.
Importantly, there were also noteworthy improvements in patients’ fatigue levels and overall quality of life, as measured by the fatigue severity scale. We found that vitamin D levels rose significantly in participants during the supplement phase, suggesting that the OFS has potential benefits beyond just zinc.
In conclusion, while this study reveals the OFS improved inflammatory symptoms, fatigue, and quality of life, we must recognize that we did not specifically analyze zinc's isolated effects on chronic fatigue syndrome.
The supplement contained a mix of ingredients like rosehip, propolis, royal jelly, zinc, and vitamin C. While zinc was part of the mix, we observed significant results in inflammation reduction through various parameters, such as a decrease in the neutrophil-to-lymphocyte ratio and C-reactive protein levels. However, we couldn’t isolate zinc's effects individually, as it was evaluated alongside other components.
Importantly, there were also noteworthy improvements in patients’ fatigue levels and overall quality of life, as measured by the fatigue severity scale. We found that vitamin D levels rose significantly in participants during the supplement phase, suggesting that the OFS has potential benefits beyond just zinc.
In conclusion, while this study reveals the OFS improved inflammatory symptoms, fatigue, and quality of life, we must recognize that we did not specifically analyze zinc's isolated effects on chronic fatigue syndrome.
Read More
User Reviews
USERS' SCORE
Good
Based on 8 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Relieves fatigue effectively
This product effectively alleviates fatigue. I consume it when I exercise rigorously, and I notice I feel less exhausted the next day. Additionally, it provides excellent sleep quality, making it a good choice for a restorative night's rest.
Read More
7.5
Boosted energy
3 people found this helpful
Working formula. Strength training often happens late in the evening, leaving little time for recovery, resulting in fatigue in the morning. However, thanks to this ZMA formula from Utrezky, I feel invigorated, full of strength and energy. The value for money is impeccable.
Read More
7.5
Better sleep quality
Before going to bed, I recommend drinking it as it improves sleep quality and alleviates fatigue.
Read More
7.5
Sleep improvement
Great! I've been taking zinc magnesium aspartate for a few weeks, and I'm genuinely impressed. As someone who seeks to enhance sleep quality and aid muscle recovery, this supplement has become a staple. I've noticed falling asleep more easily and waking refreshed. My workouts feel more productive, and I experience less fatigue post-exercise.
Read More
6
Reduced fatigue
1 people found this helpful
Good nourishing tonic. Recommended by friends familiar with supplements, I purchased it for its tonic properties. I found the zinc effective in combating fatigue and improving male function. Although I now use a cheaper alternative, I remain satisfied with this product.
Read More
Frequently Asked Questions
7.5
Sleep improvement
Great! I've been taking zinc magnesium aspartate for a few weeks, and I'm genuinely impressed. As someone who seeks to enhance sleep quality and aid muscle recovery, this supplement has become a staple. I've noticed falling asleep more easily and waking refreshed. My workouts feel more productive, and I experience less fatigue post-exercise.
7.5
Better sleep quality
Before going to bed, I recommend drinking it as it improves sleep quality and alleviates fatigue.
9
Relieves fatigue effectively
This product effectively alleviates fatigue. I consume it when I exercise rigorously, and I notice I feel less exhausted the next day. Additionally, it provides excellent sleep quality, making it a good choice for a restorative night's rest.
7.5
Boosted energy
3 people found this helpful
Working formula. Strength training often happens late in the evening, leaving little time for recovery, resulting in fatigue in the morning. However, thanks to this ZMA formula from Utrezky, I feel invigorated, full of strength and energy. The value for money is impeccable.
7.5
Effective recovery
I think my sleep quality has improved. It works better for me than melatonin and CBD. I also find it helpful for recovering from fatigue after intense exercise. The capsules may be a bit large for some Japanese people and can be hard to swallow.
8
Beta-glucan shows cognitive benefits
We conducted a study exploring the effects of beta-glucan combined with vitamins, including vitamin B6, on individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). This research involved a 36-week trial where 65 participants were split into two groups: one received a daily supplement containing beta-glucan and vitamins, while the other received a placebo.
While the beta-glucan supplementation showed promising results in reducing cognitive fatigue, the specific impact of vitamin B6 on chronic fatigue syndrome was not clearly determined. This is because vitamin B6 was part of a combination treatment, making it difficult to assess its isolated benefits.
Ultimately, we observed that yeast-derived beta-glucan might hold potential in alleviating cognitive challenges associated with ME/CFS, which opens up avenues for further research. However, it’s important to remember that additional studies are needed to fully understand how vitamin B6 and other components contribute to this condition.
While the beta-glucan supplementation showed promising results in reducing cognitive fatigue, the specific impact of vitamin B6 on chronic fatigue syndrome was not clearly determined. This is because vitamin B6 was part of a combination treatment, making it difficult to assess its isolated benefits.
Ultimately, we observed that yeast-derived beta-glucan might hold potential in alleviating cognitive challenges associated with ME/CFS, which opens up avenues for further research. However, it’s important to remember that additional studies are needed to fully understand how vitamin B6 and other components contribute to this condition.
4
Vitamin B6 and CFS relationship
We observed the functional status of vitamin B6, also known as pyridoxine, in patients suffering from chronic fatigue syndrome (CFS). Our study involved comparing 12 untreated CFS patients with 18 healthy individuals, matched for age and sex.
To assess the vitamin B6 status, we measured aspartate aminotransferase (AST) levels, among other key enzymes. Our findings revealed that the basal activity of AST was significantly lower in the CFS patients compared to the healthy controls.
This trend was consistent for other vitamins related to fatigue, like riboflavin and thiamine, where basal activity was also found to be lower in CFS patients. Importantly, even after supplementation in the lab, the overall activation ratios between both groups didn’t differ significantly.
Although our results suggest a reduced functional status of vitamin B6 in CFS patients, the lack of significant changes after vitamin activation indicates that vitamin B6 treatment alone may not be a definitive answer to combatting chronic fatigue syndrome. More research is necessary to understand the full role of B6 and its potential benefits.
To assess the vitamin B6 status, we measured aspartate aminotransferase (AST) levels, among other key enzymes. Our findings revealed that the basal activity of AST was significantly lower in the CFS patients compared to the healthy controls.
This trend was consistent for other vitamins related to fatigue, like riboflavin and thiamine, where basal activity was also found to be lower in CFS patients. Importantly, even after supplementation in the lab, the overall activation ratios between both groups didn’t differ significantly.
Although our results suggest a reduced functional status of vitamin B6 in CFS patients, the lack of significant changes after vitamin activation indicates that vitamin B6 treatment alone may not be a definitive answer to combatting chronic fatigue syndrome. More research is necessary to understand the full role of B6 and its potential benefits.
8
Magnesium potentially benefits CFS patients
We investigated the relationship between magnesium levels in red blood cells and chronic fatigue syndrome (CFS). A case-control study revealed that CFS patients had lower magnesium levels than healthy individuals.
In a randomized, double-blind trial, 32 CFS patients received either magnesium sulphate or a placebo for six weeks. Those treated with magnesium reported significant improvements in energy, emotional wellbeing, and pain relief, with twelve out of fifteen feeling better.
In contrast, only three out of seventeen patients on placebo reported any improvement. Overall, these findings suggest that magnesium treatment may positively impact the wellbeing of those suffering from CFS.
In a randomized, double-blind trial, 32 CFS patients received either magnesium sulphate or a placebo for six weeks. Those treated with magnesium reported significant improvements in energy, emotional wellbeing, and pain relief, with twelve out of fifteen feeling better.
In contrast, only three out of seventeen patients on placebo reported any improvement. Overall, these findings suggest that magnesium treatment may positively impact the wellbeing of those suffering from CFS.
References
- Lacasa M, Alegre-Martin J, Sentañes RS, Varela-Sende L, Jurek J, et al. Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. 2023;15. doi:10.3390/nu15214504
- Heap LC, Peters TJ, Wessely S. Vitamin B status in patients with chronic fatigue syndrome. J R Soc Med. 1999;92:183.
- Alraek T, Lee MS, Choi TY, Cao H, Liu J. Complementary and alternative medicine for patients with chronic fatigue syndrome: a systematic review. BMC Complement Altern Med. 2011;11:87. doi:10.1186/1472-6882-11-87
- Manuel y Keenoy B, Moorkens G, Vertommen J, Noe M, Nève J, et al. Magnesium status and parameters of the oxidant-antioxidant balance in patients with chronic fatigue: effects of supplementation with magnesium. J Am Coll Nutr. 2000;19:374.
- Takahashi H, Imai K, Katanuma A, Sugaya T, Hisano K, et al. [A case of chronic fatigue syndrome who showed a beneficial effect by intravenous administration of magnesium sulphate]. Arerugi. 1992;41:1605.
- Uchida A. [Therapy of chronic fatigue syndrome]. Nihon Rinsho. 1992;50:2679.
- Cox IM, Campbell MJ, Dowson D. Red blood cell magnesium and chronic fatigue syndrome. Lancet. 1991;337:757.
- Ranisavljev M, Stajer V, Todorovic N, Ostojic J, Cvejic JH, et al. The effects of 3-month supplementation with synbiotic on patient-reported outcomes, exercise tolerance, and brain and muscle metabolism in adult patients with post-COVID-19 chronic fatigue syndrome (STOP-FATIGUE): a randomized Placebo-controlled clinical trial. Eur J Nutr. 2024;64:28. doi:10.1007/s00394-024-03546-0
- Noce A, Marrone G, Di Lauro M, Vita C, Montalto G, et al. Potential Anti-Inflammatory and Anti-Fatigue Effects of an Oral Food Supplement in Long COVID Patients. Pharmaceuticals (Basel). 2024;17. doi:10.3390/ph17040463
- Imai K, Yamano T, Nishi S, Nishi R, Nishi T, et al. Epipharyngeal Abrasive Therapy (EAT) Has Potential as a Novel Method for Long COVID Treatment. Viruses. 2022;14. doi:10.3390/v14050907
- Castro-Marrero J, Zaragozá MC, López-Vílchez I, Galmés JL, Cordobilla B, et al. Effect of Melatonin Plus Zinc Supplementation on Fatigue Perception in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial. Antioxidants (Basel). 2021;10. doi:10.3390/antiox10071010
- Maes M, Leunis JC. Normalization of leaky gut in chronic fatigue syndrome (CFS) is accompanied by a clinical improvement: effects of age, duration of illness and the translocation of LPS from gram-negative bacteria. Neuro Endocrinol Lett. 2008;29:902.
- Maes M, Mihaylova I, De Ruyter M. Lower serum zinc in Chronic Fatigue Syndrome (CFS): relationships to immune dysfunctions and relevance for the oxidative stress status in CFS. J Affect Disord. 2006;90:141.
